Research Paper Volume 11, Issue 13 pp 4579—4586

Ketones improves Apolipoprotein E4-related memory deficiency via sirtuin 3

Figure 1. Ketones improve learning and memory abilities of ApoE 4 mice. ApoE4 and ApoE3 mice were randomly divided into ketone treatment (Ket) or normal saline (NS) groups. After three months of treatment, all mice were tested in the Morris water maze. (A) Escape latency (s); (B) Velocity (cm/s); (C) Duration in the target quadrant (s); (D) Frequency in the target quadrant. N= 10–11 per group, #p<0.05, ApoE3-NS vs. ApoE4-NS. *p<0.05, **p<0.01, ApoE4-NS vs. ApoE4-Ket.