Figure 6. MIR22HG expression in esophageal tissues and pathway involved by MIR22HG negative correlated genes. (A) MIR22HG expression of esophageal adenocarcinomas (EAC), high grade dysplasia (LDH), low grade dysplasia (LDH) and Barrett’s measured by RT-PCR. There is no significant different among them (p > 0.05). (B) MIR22HG expression from TCGA RNA-seq data including 88 esophageal adenocarcinomas (EAC) and 95 esophageal squamous cell carcinomas (ESCC). There is no significant different between EAC vs. ESCC (p > 0.05). (C and D), DAVID pathway analysis of MIR22HG negative correlated genes indicating that the cell cycle and DNA replication pathways were the most significantly involved pathways in both EAC and ESCC (p < 0.001).