Research Paper Volume 11, Issue 13 pp 4654—4671

Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD


Figure 1. PM induced several potential transcription factors in a dose-dependent manner in normal lung cells. (A) The flowchart represents the procedure of microarray chips established in human pulmonary fibroblasts. (B) Detailed heatmaps highlight the significantly up- and down-regulated genes after PM treatment, that were normalized gene expression from the microarray database analysis. (C) The ranking of candidate transcription factors by IPA database of microarray from PM treatment compared with the sham group in human pulmonary fibroblasts. The cut-off was a 1.5-fold change.