Review Volume 11, Issue 13 pp 4757—4771

Figure 3. Schematic representation of the proposed mechanism of circRNAs in leukemia. CircRNAs and f-circRNAs could be transcribed separately from genes and fusion genes. CircRNAs that predominantly distribute in cytoplasm, play parts in leukemia mainly via sponging specific miRNAs and thus modulating mRNAs roles in cell proliferation and apoptosis. Exosomes are possible transport vectors that facilitate circRNAs circulating in blood and others and subsequently promoting leukemogenesis and progression.