Research Paper Volume 11, Issue 15 pp 5300—5318

Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2

Figure 3. Over-expression of miR-199a inhibits the migration, invasion and proliferation of U251 cells. (AB) the migration ability of U251 cells measured by scratch test (Scale bar = 100 μM). (CD) the invasion ability of U251 cells evaluated by Transwell assay (Scale bar = 50 μM). (EF) the proliferation ability of U251 cells assessed by EdU assay (Scale bar = 50 μM). * p < 0.05 compared with the corresponding NC. The results were measurement data, presented as mean ± standard deviation. Comparison between two groups using independent sample t test. The experiment was repeated three times. mimic-NC, cells transfected with mimic-negative control; miR-199a mimic, cells transfected with miR-199a mimic; inhibitor-NC, cells transfected with inhibitor-negative control; miR-199a inhibitor, cells transfected with miR-199a inhibitor.