Research Paper Volume 11, Issue 15 pp 5300—5318

Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2

Figure 8. MSCs-derived exosomal miR-199a inhibits the proliferation, invasion and migration of glioma cells. (AB) the invasion ability of U251 cells, assessed by Transwell assay (Scale bar = 50 μM). (CD) the migration ability of U251 cells, measured by scratch test (Scale bar = 100 μM). (EF) the proliferation ability of U251 cells, evaluated by EdU assay (Scale bar = 50 μM). * p < 0.05. The results were measurement data, presented as mean ± standard deviation. Paired t-test was used for the analysis. The experiment was repeated three times. MSCs-mimic-NC, glioma cells co-cultured with mesenchymal stem cells and transfected with mimic-negative control; MSCs-miR-199a mimic, glioma cells co-cultured with mesenchymal stem cells and transfected with miR-199a mimic.