Editorial Volume 11, Issue 13 pp 4305—4307
A preclinical model for phenogroup 3 HFpEF
Figure 1. Engineering the Alport mouse to become a closer model for phenogroup 3 HFpEF patients. The Alport mouse represents multiple cardiac and extracardiac features of phenogroup 3 HFpEF patients (bound by green lines). Other HFpEF comorbidities not displayed or investigated in the Alport mouse (bound by orange lines) need to be addressed in order to engineer the mouse to better mimic phenogroup 3 HFpEF patients.