Figure 1. IGF1 was down-regulated and PI3K/Akt signaling pathway was dys-regulated in periodontitis periodontal tissues compared with healthy periodontal tissues. (A) Heatmap of top 15 up-regulated or down-regulated mRNAs between periodontitis periodontal tissues and healthy periodontal tissues. (B, C) KEGG pathway enrichment analysis using GSEA. PI3K/Akt signaling pathway was one of pathways that were inactivated in periodontal tissues with periodontitis compared with healthy samples. (D–E) Joyplot and dotplot of abnormally regulated signaling pathway in periodontitis tissues compared with the that in healthy samples.