Figure 2. LncRNA MEG3 was down-regulated in periodontitis periodontal tissues compared with healthy periodontal tissues and correlated with IGF1 via miR-27a-3p. (A) Heatmap of top 15 up-regulated or down-regulated lncRNAs between periodontitis periodontal tissues and healthy periodontal tissues. (B) Co-expression network between differentially expressed lncRNAs and mRNAs in R software and Cytoscape. Screening conditions was Pearson Correlation Coefficient>0.75 and P<0.05. LncRNA MEG3 was positively correlated to IGF1. (C) 3 miRNAs directly targeting MEG3 and IGF1 were screened by DIANA Tools and HMDD analysis, including miR-27a-3p. (D) Predicted binding sites of miR-27a-3p targeting MEG3 and IGF1.