Research Paper Volume 11, Issue 15 pp 5334—5350

Down-regulation of long non-coding RNA MEG3 suppresses osteogenic differentiation of periodontal ligament stem cells (PDLSCs) through miR-27a-3p/IGF1 axis in periodontitis

Figure 5. LncRNA MEG3 was correlated to IGF1 via MiR-27a-3p. (A) IGF1 expression in periodontitis periodontal tissues compared with healthy periodontal tissues. (B) Expression of IGF1 in 0h, 24h, 7d, 14d and 21d after osteogenic induction. (C) MiR-27a-3p directly targeted IGF1. (DF) Expression of MEG3, miR-27a-3p and IGF1 in PDLSCs of each group. ** P < 0.01, compared with the NC group.