Figure 2. LINC00511 mediates the cell proliferation and apoptosis of HOS cells in vitro. (A) The relative expression level of LINC00511 was changed in HOS cells transfected with p-LINC00511- or LINC00511-targeting siRNA. P-LINC00511 is a LINC00511 overexpression vector, and its transfection induced a high level of LINC00511 expression. In contrast, transfection of specific LINC00511-targeting siRNA caused low expression levels of LINC00511 in HOS cells. (B) CCK-8 assays showed that the proliferation ability is changed in HOS cells with LINC00511 dysregulation. Up- or downregulation of LINC00511 was induced by pre-transfection with p-LINC00511 or specific siRNA. (C–D) Colony formation ability of HOS cells with altered expression of LINC00511. (E–F) Apoptosis rate of HOS cells with altered expression of LINC00511. *P < 0.05 compared to the NC group.