Research Paper Volume 11, Issue 15 pp 5433—5444

Genome-wide association study identifies CBFA2T3 affecting the rate of CSF Aβ42 decline in non-demented elders

Figure 1. Manhattan plot (A), quantile-quantile plot (B) and regional plots (C and D) for the GWAS of longitudinal changes of CSF Aβ42. (A) A genome-wide significant association (P < 5×10−8; red line) with longitudinal change of CSF Aβ42 was identified on chromosome 16 within CBFA2T3. Suggestive associations are at the threshold of P < 1×10−5 (blue line). (B) Quantile-quantile plot. (C) Regional association results for the 88.9 Mb to 89.2 Mb region of chromosome 16. (D) Association results for the 88.9 Mb to 89.2 Mb region of chromosome 16 controlling for rs13333659.