Figure 1. Manhattan plot (A), quantile-quantile plot (B) and regional plots (C and D) for the GWAS of longitudinal changes of CSF Aβ42. (A) A genome-wide significant association (P < 5×10−8; red line) with longitudinal change of CSF Aβ42 was identified on chromosome 16 within CBFA2T3. Suggestive associations are at the threshold of P < 1×10−5 (blue line). (B) Quantile-quantile plot. (C) Regional association results for the 88.9 Mb to 89.2 Mb region of chromosome 16. (D) Association results for the 88.9 Mb to 89.2 Mb region of chromosome 16 controlling for rs13333659.