**Figure 3.** **CRP increases cellular oxidative stress and oxidative stress-downstream signaling in HAoSMCs.** (**A, B**) Scatter dot plots and arithmetic means ± SEM (n=8; arbitrary units, a.u.) of *NOX4* (**A**) and *CYBA* (**B**) relative mRNA expression in HAoSMCs treated with control (CTR) or 10 µg/ml recombinant human CRP. (**C**) Scatter dot plots and arithmetic means ± SEM (n=6; a.u.) of normalized total antioxidant capacity of HAoSMCs treated with control (CTR) or 10 µg/ml recombinant human CRP. (**D**) Representative original Western blots and scatter dot plots and arithmetic means ± SEM (n=5; a.u.) of normalized phospho-p38/total p38/GAPDH protein ratio in HAoSMCs treated with control (CTR) or 10 µg/ml recombinant human CRP. (**E-G**) Scatter dot plots and arithmetic means ± SEM (n=8; a.u.) of *MMP2* (**E**), *MMP9* (**F**) and *PAI1* (**G**) relative mRNA expression in HAoSMCs treated with control (CTR) or 10 µg/ml recombinant human CRP. (**H**) Representative original Western blots and scatter dot plots and arithmetic means ± SEM (n=7; a.u.) of normalized caspase 3/GAPDH and cleaved caspase 3/GAPDH protein ratio in HAoSMCs treated with control (CTR) or 10 µg/ml recombinant human CRP. *(p<0.05), **(p<0.01), ***(p<0.001) significant vs. control HAoSMCs.