Research Paper Volume 11, Issue 15 pp 5445—5462

Impact of C-reactive protein on osteo-/chondrogenic transdifferentiation and calcification of vascular smooth muscle cells


Figure 5. Inhibition of p38 MAPK blunts CRP-induced osteogenic signaling in HAoSMCs. (A-E) Scatter dot plots and arithmetic means ± SEM (n=5; arbitrary units, a.u.) of MMP2 (A), MMP9 (B), PAI1 (C), CBFA1 (D) and ALPL (E) relative mRNA expression in HAoSMCs treated with control (CTR) or 10 µg/ml recombinant human CRP without and with 10 µM p38 MAPK inhibitor SB203580 (SB). **(p<0.01), ***(p<0.001) significant vs. control HAoSMCs; ††(p<0.01) significant vs. HAoSMCs treated with CRP alone.