Research Paper Volume 11, Issue 15 pp 5548—5569

Ginseng increases Klotho expression by FoxO3-mediated manganese superoxide dismutase in a mouse model of tacrolimus-induced renal injury

Figure 1. Effect of KRGP administration on Tac-induced renal fibrosis in a mouse model. (A and B) Histological analysis in the renal cortex in mice treated with Tac for 4 weeks showed striped tubulointerstitial fibrosis, mononuclear cell infiltration, and tubular atrophy. KRGP treatment significantly reduced these damages compared with those caused by Tac treatment. (CF) Immunoblotting analysis of e-cadherin, α-smooth muscle actin (α-SMA), and transforming growth factor β1 (TGF-β1) in the renal cortex. The relative optical densities of bands in each lane were normalized to that of each β-actin band in the same gel. Note that the expression of e-cadherin was restored and that of α-SMA and TGF-β1 was decreased after combined treatment with KRGP. Bar = 100 μm. Data are presented as mean ± SE. n = 8. #P < 0.05.