Research Paper Volume 11, Issue 15 pp 5593—5612

TGFβ1- miR-140-5p axis mediated up-regulation of Flap Endonuclease 1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

Figure 6. miR-140-5p partially reverses the effect of FEN1 in vitro. (A and B) Representative images of transwell chamber assays and quantification of the number of cells that successfully migrated or invaded through the basement membrane. Data represent mean ± SD of three independent experiments, *P < 0.05, **P < 0.01. (C and D) Western blot analysis of EMT markers in HCC cells overexpressing FEN1 which were transfected with miR-140-5p.