Research Paper Volume 11, Issue 15 pp 5593—5612

TGFβ1- miR-140-5p axis mediated up-regulation of Flap Endonuclease 1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

Figure 7. miR-140-5p partially reverses the effect of FEN1 in vivo. (A) Images of nude mice bearing subcutaneous tumor xenografts. (B) Xenograft tumor growth curves; n = 5 per group, *P < 0.05 and **P < 0.01. (C) Weight growth curves of nude mice, n = 5 per group. (D) Weights of tumors derived from euthanized nude mice at the endpoint; n = 5 per group, **P < 0.01. (E) IHC staining of FEN1 and EMT markers such as E-cadherin, N-cadherin and vimentin in xenograft tumor tissues; original magnification, 200 x for the upper panels and 400 x for the lower panels in each figure.