Research Paper Volume 11, Issue 15 pp 5593—5612

TGFβ1- miR-140-5p axis mediated up-regulation of Flap Endonuclease 1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

Figure 9. TGF-β1 acts through miR-140-5p to up-regulate FEN1 in promoting EMT. (A and B) Western blot analysis showing the effect of silenced FEN1 on EMT repression induced by TGF-β1. (C and D) Western blot analysis of the effect of miR-140-5p on the expression of established EMT markers and FEN1 in HCC cells after treatment with TGF-β1.