Editorial Volume 11, Issue 15 pp 5298—5299

Figure 1. Altered processes in Subcutaneous WAT during the first stages of aging. Subcutaneous WAT (scWAT) shows a defect in hypertrophy and/or hyperplasia, fibrosis and inflammatory processes and insulin resistance (IR) appears progressively in this tissue during the first stages of aging. Insulin receptor substrate (IRS), phosphoinositol-3-kinase (PI3K), glucose transporter (GLUT), c-Jun kinases (JNK), protein kinase B (PKB or AKT), phosphatidylinositol (3,4,5)-tris- phosphate (PIP3), phosphatidylinositol 4,5-bisphosphate (PIP2), free fatty acids (FFA) and diacylglycerol (DAG).