Editorial Volume 11, Issue 15 pp 5298—5299

The risk of jiggly fat in aging

Figure 1. Altered processes in Subcutaneous WAT during the first stages of aging. Subcutaneous WAT (scWAT) shows a defect in hypertrophy and/or hyperplasia, fibrosis and inflammatory processes and insulin resistance (IR) appears progressively in this tissue during the first stages of aging. Insulin receptor substrate (IRS), phosphoinositol-3-kinase (PI3K), glucose transporter (GLUT), c-Jun kinases (JNK), protein kinase B (PKB or AKT), phosphatidylinositol (3,4,5)-tris- phosphate (PIP3), phosphatidylinositol 4,5-bisphosphate (PIP2), free fatty acids (FFA) and diacylglycerol (DAG).