Research Paper Volume 11, Issue 15 pp 5744—5756

miR-627-3p inhibits osteosarcoma cell proliferation and metastasis by targeting PTN

Figure 4. MiR-627-3p inhibits osteosarcoma cell metastasis. (AD) After overexpression/inhibition of miR-627-3p in HOS and MG63 cells, Transwell assays with or without Matrigel were performed, and counts of migrated cells were made. The results represent the mean ± SD of three experiments. ** P< 0.05. (EH) Western blot and real-time PCR analyses of MMP2 expression in osteosarcoma cells transfected with miR-627-3p mimic/inhibitor. Data are shown as mean ± SEM. ** P< 0.05.