Research Paper Volume 11, Issue 15 pp 5786—5806

A defined human aging phenome

Figure 5. The aging phenome. (A) The prevalence of features in the elderly (manually curated literature describing 76,928,696 individuals). HDL: High density lipoprotein, IGF-1: Insulin like growth factor-1, LDL: Low density lipoprotein (B) Agglomerative hierarchical clustering using uncentered similarity and average linkage of aging and genetic diseases (red: primary mitochondrial disorders, green: non-mitochondrial disorders, purple: segmental progerias). The approximately unbiased value is shown in red while the bootstrap probability value is shown in blue. ADOA: Autosomal dominant optic atrophy, MELAS: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes, MERRF: Myoclonic epilepsy with ragged-red fibers, XPA: Xeroderma pigmentosum complementation group A.