Research Paper Volume 11, Issue 17 pp 6674—6690

RPN2 promotes metastasis of hepatocellular carcinoma cell and inhibits autophagy via STAT3 and NF-κB pathways

Figure 10. Schematic model for the mechanism of RPN2-mediated STAT3/p65 phosphorylation pathway in HCC cells. In HCC cells, RPN2 resulted in increased phosphorylation of STAT3/p65 and therefore enhanced transcription of MMP-9, which promoted cancer malignancy.