Research Paper Volume 11, Issue 15 pp 5848—5863

Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma

Figure 2. Sodium cantharidate represses growth, migration, and STAT3 activation in osteosarcoma cells. (A) Half-maximum inhibitory concentration (IC50) values obtained for SC. (B) MTT assay results in cultured MG63 and U2OS cells exposed to SC. Migration assay results in MG63 (C) and U2OS (D) cells treated for 24 h with DMSO (vehicle) or SC. Magnification, 200x. Error bars indicate SD. **p < 0.01 vs. DMSO, n = 3. (E). Western blot analyses of protein expression in MG63 and U2OS cells exposed over 24 h to DMSO or SC.