Research Paper Volume 11, Issue 17 pp 6734—6761

MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer

Figure 5. MiR-330-3p induces tumorigenesis in vivo. (A) A549 and HCC827 cells stably transfected with NC-LV, OE-miR-330-3p-LV or anti-miR-330-3p-LV were injected subcutaneously into nude mice. Four weeks after the injection, mice were photographed and killed. Tumor growth curves were obtained. (B) Representative bioluminescence images of tumor burden in the mice that received subcutaneous injection of indicated cells. (C) Survival curves represent the duration from injection until four weeks when mice were killed. *P < 0.05, **P < 0.01.