Research Paper Volume 11, Issue 17 pp 6734—6761

MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer

Figure 6. MiR-330-3p induces tumor metastasis and angiogenesis in BM model. (A) Immunohistochemical analysis of PCNA, cylinD1, Bcl-2, caspase3, Bax, CD44 and β-catenin expression in tissue sections of GFP-labeled tumors isolated from mice injected with A549 and HCC827 cells transfected with NC-LV, OE-miR-330-3p-LV or anti-miR-330-3p-LV. (B, C) Representative images of CD31-positive endothelial cells in tumor tissues of mice (B) and NSCLC patients (C). *P < 0.05, **P < 0.01, values are mean ± SD, one-way ANOVA test. (D) MRI images of metastatic tumors in the brain. Representative MRI of tumors is shown. A representative experiment of three was reported.