Expression of Concern
This article is currently under investigation. We strongly recommend that this article is not cited until the investigation is completed.
This article is currently under investigation. We strongly recommend that this article is not cited until the investigation is completed.
Research Paper Volume 11, Issue 17 pp 6734—6761
MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer
Figure 6. MiR-330-3p induces tumor metastasis and angiogenesis in BM model. (A) Immunohistochemical analysis of PCNA, cylinD1, Bcl-2, caspase3, Bax, CD44 and β-catenin expression in tissue sections of GFP-labeled tumors isolated from mice injected with A549 and HCC827 cells transfected with NC-LV, OE-miR-330-3p-LV or anti-miR-330-3p-LV. (B, C) Representative images of CD31-positive endothelial cells in tumor tissues of mice (B) and NSCLC patients (C). *P < 0.05, **P < 0.01, values are mean ± SD, one-way ANOVA test. (D) MRI images of metastatic tumors in the brain. Representative MRI of tumors is shown. A representative experiment of three was reported.