Research Paper Volume 11, Issue 17 pp 6762—6791

Knockout of p75 neurotrophin receptor attenuates the hyperphosphorylation of Tau in pR5 mouse model

Figure 7. Deletion of p75NTR reversed hyperactivity in pR5 mice at 6 months. Wt, p75KO, pR5 and pR75KO mice at 3- and 6-months of age were subjected to MWM test. Performance of mice on Day 1 to locate the visible platform was assessed by measuring total distance travelled in metres (m) and escape latency in seconds (s) at 3 months (A and B) and at 6 months (C and D) of age. Performance of mice on training Days 2-5 to locate the platform where it is submerged was assessed by measuring the total distance travelled and the escape latency during training at 3 months (E and F) and 6 months (G and H) of age. To determine memory impairment in mice, Probe Test was performed where the number of island entries or platform crossing and the percentage of time spent at the platform area by each mouse, were recorded at training Day 6, at 3 months (I and J) and 6 months (K and L) of age. Data are represented as the mean ± SEM, n=12. Statistical comparisons were performed using one-way (Day 1 and Probe Test) or two-way ANOVA (Training) and Tukey’s test. Statistical significance: *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.