Research Paper Volume 11, Issue 17 pp 6805—6838

Long non-coding RNA, HOTAIRM1, promotes glioma malignancy by forming a ceRNA network

Figure 8. Elevated HOTAIRM1 expression is associated with distinct immune and inflammatory phenotypes. (AF) Activation of T cell-mediated immune response and immune response to tumor cells is associated with HOTAIRM1 expression levels in TCGA (AC) and CGGA (DF). (G, H) Effect of HOTAIRM1 on inflammation in TCGA (G) and CGGA (H); gene expression level was normalized to z score. (IK) Expression of six inflammation-related genes in TCGA (I), CGGA (J), and independent glioma samples (K) in relation to HOTAIRM1 level. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. low-exp group (Student’s t test).