Research Paper Volume 11, Issue 18 pp 7357—7385

miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells

Figure 8. The schematic model of miR-375-3p as a role in regulating functions in CRC cells. In CRC, miR-375-3p is frequently downregulated and directly targets YAP1 and SP1 in CRC. Low expression of miR-375-3p leads to the release of YAP1 and SP1, resulting in chemoresistance and tumorigenesis. The mechanism of YAP1 mediated by miR-375-3p promoting drug resistance and proliferation is that release of YAP1 leads to YAP1 increase in CRC cells, thereby activates the downstream genes of Hippo-YAP1 pathway, causing CTGF, Cyclin D1 and BIRC5 (Survivin) upregulate, which ultimately promotes CRC proliferation and drug resistance and inhibits apoptosis.