Research Paper Volume 11, Issue 17 pp 6872—6891

Cholesterol lowering attenuates pressure overload-induced heart failure in mice with mild hypercholesterolemia

Figure 1. AAV8-LDLr gene transfer normalizes lipoprotein cholesterol levels in C57BL/6 LDLr-/- mice. Bar graphs illustrating total cholesterol (A), non-HDL cholesterol (B), VLDL cholesterol (C), IDL cholesterol (D), LDL cholesterol (E), and HDL cholesterol (F) plasma levels in C57BL/6 LDLr-/- mice at day 10 after AAV8-null gene transfer (controls) or AAV8-LDLr gene transfer. Lipoproteins were isolated by ultracentrifugation. Data are expressed as means ± SEM (n=7).