Research Paper Volume 11, Issue 17 pp 6872—6891

Cholesterol lowering attenuates pressure overload-induced heart failure in mice with mild hypercholesterolemia

Figure 2. Cholesterol lowering gene therapy improves survival, attenuates cardiac hypertrophy, and inhibits lung congestion after TAC. Kaplan-Meier survival curves during an 8 weeks follow-up period comparing survival in control TAC mice (black) and AAV8-LDLr TAC mice (red) (A). Bar graphs illustrating body weight (B), tibia length (C), heart weight (D) in control sham (n=10), AAV8-LDLr sham (n=10), control TAC (n=9), and AAV8-LDLr TAC (n=10) mice 8 weeks after operation. Left ventricular wall area (E), anterior wall thickness (F) cardiomyocyte-cross-sectional area (G), and capillary density (H) quantified by morphometric and histological analysis in control sham (n=14), AAV8-LDLr sham (n=11), control TAC (n=25), and AAV8-LDLr TAC (n=11) mice 8 weeks after operation. Bar graph illustrating wet lung weight (I) in control sham (n=10), AAV8-LDLr sham (n=10), control TAC (n=9), and AAV8-LDLr TAC (n=10) mice 8 weeks after operation. Data are expressed as means ± SEM. Insets show a 4x magnification of the boxed region.