Editorial Volume 11, Issue 17 pp 6614—6615

TLR8 reprograms human Treg metabolism and function

Figure 1. TLR8 signaling enhances anti-tumor immunity and immunotherapy. Treg cells and tumor cells have accelerated glucose metabolism and induce senescence and suppression in effector T cells during their cross-talks. TLR8 signaling inhibits glucose metabolism in Treg cells and decreases tumor-produced cAMP, resulting in reversal of responder T cell senescence and enhanced anti-tumor immune responses.