Research Paper Volume 11, Issue 17 pp 6951—6959

Kindlin-3 in platelets and myeloid cells differentially regulates deep vein thrombosis in mice

Figure 1. Determine the role of kindlin-3 in platelets and myeloid cells in regulating stenosis-induced DVT in mice. (A1A2) K3KI mice and wild type littermates were subjected to partial IVC ligation for 48 hours. After that, the IVC tissues were harvested, and thrombus weight and length were evaluated; n = 12 for each group. (B1B2) Thrombus formation was evaluated in Kindlin-3fl/flPF4 mice and Kindlin-3fl/fl littermates by partially ligating the IVC for 48 hours; n = 9 for each group. (C and D) Partial IVC ligation was applied to Kindlin-3fl/flLysM-Cre mice and Kindlin-3fl/fl littermates for either 48 hours (C1C2) or 6 hours (D1D2), and thrombus formation in these mice was evaluated; n ≥ 8 for each group. Dots represent individual experiments for each mouse and lines in dot plots represent mean. A value of P < 0.05 was considered significant.