Research Paper Volume 11, Issue 17 pp 6983—6998

Curcumin suppresses osteogenesis by inducing miR-126a-3p and subsequently suppressing the WNT/LRP6 pathway

Figure 2. The effect of curcumin on miRNA expression patterns in hADSCs. (A) Microarray analysis was performed to analyse the miRNA expression pattern in hADSCs. (B) miRNAs with at least a 2.5-fold increase or decrease in response to curcumin treatment are shown. (C) qRT-PCR detected the expression levels of miR-126a-3p in curcumin-treated hADSCs. (D) qRT-PCR detected the expression profile of miR-126a-3p during osteogenic differentiation of hADSCs. Quantitative data are presented as the mean ± S.D. (n =3). *P<0.05; **P<0.01; ***P<0.001.