Research Paper Volume 11, Issue 17 pp 6999—7020

Prognostic value and immune infiltration of novel signatures in clear cell renal cell carcinoma microenvironment

Figure 1. Association between immune/stromal/Estimate score and prognosis in TCGA after ESTIMATE algorithm processed. (AB) Estimate score was significantly associated with higher ISUP grade and AJCC stage (p<0.001). The highest Estimate score was found in the most progressive clinicopathological stage, G4 and stage IV. (C) Survival curves indicated that elevated immune score significantly correlated with poor overall survival in 533 ccRCC patients (p=0.001, 1165 vs. 1217 days). (D) Increased stromal score significantly associated with shorter OS (p=0.002, 1117.5 vs. 1230 days). (E) Significant Estimate score also predict significant OS for ccRCC patients (p=0.003, 1172.5 vs. 1223.5 days).