Figure 3. Significant modular analysis and function enrichment analysis based on PPI network. (A) PPI network was constructed using a total of 77 commonly up-regulated DEGs. MCODE, plug-in of Cytoscape, was used to detect most significant co-regulated modular. The most significant modular including AGPAT9, AQP7, HMGCS2, KLF15, MLXIPL and PPARGC1A, was marked in yellow. (B) functional annotations indicated that 77 DEGs were mostly involved in carbohydrate digestion and absorption, fatty acid transmembrane transport activity, PPAP signaling pathway, response to methionine, insulin resistance, water channel activity, enamel mineralization, negative regulation of mitochondrial fission, etc.