Research Paper Volume 11, Issue 17 pp 6999—7020

Prognostic value and immune infiltration of novel signatures in clear cell renal cell carcinoma microenvironment

Figure 5. Prognostic validation of MLXIPL and PPARGC1A in FUSCC cohort. (AB) To validate AQP9 mRNA expression profile in ccRCC tissues, we performed RT-qPCR using 380 paired tumor and normal samples with available clinical follow-up data from a real-world cohort. It revealed dramatically increased MLXIPL and decreased PPARGC1A mRNA expression in ccRCC samples than normal tissues. (CF) Survival curves suggested that patients with elevated MLXIPL and decreased PPARGC1A mRNA levels significantly correlated with poorer PFS and OS (p<0.001).