Research Paper Volume 11, Issue 17 pp 7021—7035

Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging

Figure 2. NRF2 expression in cultured EPCs was reduced with advancing age. Low-magnification images of NRF2 expression in different age groups are shown in (A), with quantification in (B). High-magnification confocal images of NRF2 expression are shown in (C). NRF2 expression was detected in the cytoplasm (white arrows) and/or nuclei (red arrows) in younger cells, while little or no NRF2 expression was detected in middle-aged and aged cells (yellow arrows). *P<0.05. n=5. Y, young; MA, middle-aged; A, aged. Scale Bar: (A) 100 μm, (C) 20 μm.