Research Paper Volume 11, Issue 17 pp 7036—7050

Enhancing the retrograde axonal transport by curcumin promotes autophagic flux in N2a/APP695swe cells

Figure 6. The mechanism of curcumin promoting autophagic flux in AD. First, curcumin induces autophagy by regulating Beclin1, Atg5, and Atg16. Then, curcumin promotes the retrograde axonal transport of autophagy by increasing the expression of dynein, Huntingtin, and RILP. By the time, it increases the dynactin and BICD2, also promoting the binding of BICD2 and LC3. Finally, it promotes the binding of autophagy corpuscles and lysosomes, thus enhances autophagy flux.