Research Paper Volume 11, Issue 17 pp 7123—7149

Chromobox homolog 8 (CBX8) Interacts with Y-Box binding protein 1 (YBX1) to promote cellular proliferation in hepatocellular carcinoma cells

Figure 3. CBX8 increase levels of CyclinD1 through YBX1. Results of GSEA were plotted to visualize the correlation between the expression of CBX8 (A) or YBX1 (B) and gene signatures of YBX1 target up or KEGG cell cycle in the TCGA cohort (P < 0.01). (CF) Both protein and mRNA levels of CyclinD1 in Huh7 and MHCC-97H cells-overexpressing CBX8 or YBX1 knock-down as detected by western blotting and q-RT-PCR.