Research Paper Volume 11, Issue 17 pp 7187—7196

STAT3 inhibitor sensitized KRAS-mutant lung cancers to RAF inhibitor by activating MEK/ERK signaling pathway

Figure 3. The combination of AZ628 and BP-1-102 induced cell apoptosis increase. (A) Flow cytometry was performed to detect cell apoptosis induced by single or combination drugs in KRAS(G12D) H838, KRAS(G12S) H292, KRAS(G12V) H441, KRAS(WT) H838, H661and H1650 cells. * p<0.05. **p<0.01. ***p<0.001. (B) Western blot was performed to detect cleaved PRAP protein levels caused by single or combination drugs in different cells.