Research Paper Volume 11, Issue 18 pp 7416—7441

Figure 8. ABR analysis and EP measurement in KI mice after noise exposure. (A) ABR audiograms tracking changes of thresholds after one episode of a two-hour, 100 dB SPL, 8-16 kHz band-pass noise exposure. ABR thresholds of both groups recovered to the baseline level at 15 days after noise exposure (P>0.05 for both genotypes, two-way ANOVA followed by Bonferroni post-test). (B) EPs didn’t change in both wild-type and homozygous mice at day 15 of noise exposure (P>0.05, Student’s unpaired t-test with Welch’s correction). Baseline EPs were obtained by pooling data from young individuals less than 20 weeks old in Figure 3. (C) Comparison of Wave I latencies of day 0 (pre-exposure) and day 15 at 90dB SPL showing that homozygous mice presented a tendency of prolonged latency in frequencies above 11.3 kHz (*P=0.021, F_(1,5)=11.003 at 16 kHz and *P=0.016, F_(1,5)=12.961 at 22.6 kHz, two-way ANOVA followed by Bonferroni post-test). (D) Summary of ABR Wave I amplitude showing no significant difference between the two genotypes (P>0.05 for all frequencies, two-way ANOVA followed by Bonferroni post-test). ΔAmplitude=day 15 amplitude at 90 dB SPL - day 0 amplitude at 90 dB SPL.