Figure 4. FOXA1 mutations in human breast cancer. (A) The pie chart generated using COSMIC summarizes the observed mutation types, including nonsense substitutions, missense substitutions, synonymous substitutions, in-frame insertions, frameshift insertions, in-frame deletions, frameshift deletions, and complex mutations. (B) As determined using cBioPortal, the FOXA1 mutation frequency was less than 8% in patients with breast cancer. A total of 33 mutation sites were detected between amino acids 0 and 472. The FOXA1 mutation occurs primarily in the Forkhead domain.