Research Paper Volume 11, Issue 20 pp 8760—8776

Adipose tissue-derived omentin-1 attenuates arterial calcification via AMPK/Akt signaling pathway

Figure 6. Schematic model of the omentin-1 induced anti-calcification effect. In this study, we demonstrate that omentin-1, mainly derived from visceral fat tissues, induces the AMPK/Akt signaling activation in VSMCs and thus attenuates the expression of Runx2, reduces ALP activity and decreases OC secretion. As a result, arterial calcification is alleviated.