Research Paper Volume 11, Issue 17 pp 7242—7256

Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions

Figure 8. Graphical abstract of the senescence pathway in Idh2-deficient conditions.Idh2 deficiency-induced ROS generation accelerates p53 and p21 signaling pathways which inhibit Cdk2 expression. Furthermore, overexpression of Idh2 prevented senescence-associated phenotypes by decreasing the levels of senescence signaling pathway-associated proteins p21 and p53.