Research Paper Volume 11, Issue 17 pp 7257—7273

Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer’s disease

Figure 2. TLR2 knockout increased the anxiety and depression states in mouse models of AD. (A) Representative track plots from open field maze test. (B) The exploration times in the central area were significantly shorter in AD, TLR2, and AD-TLR2KO mice compared with WT mice (p<0.05). Moreover, the exploration time in the central area among AD-TLR2KO mice was shorter than that among AD mice (p<0.05). (C) The total traveled distance of AD-TLR2KO mice was shorter compared with WT mice (p<0.05). (D) In the tail suspension test, the rest time for AD-TLR2KO mice significantly increased compared with WT mice (p<0.05). (E) However, the time in enclosed arms did not show a significant difference among the groups in the elevated plus maze test (n=11~15/group).