Research Paper Volume 11, Issue 17 pp 7257—7273

Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer’s disease

Figure 3. Aβ deposition in mouse brains. (A) Representative immunofluorescence images of Aβ deposition in mouse brains (4x, 20x: cortex; 10x: hippocampus). (B) Representative Aβ levels in brain tissues detected by Western blots. (C) Results from quantitative analyses of Western blots showed that Aβ levels were significantly higher in AD and AD-TLR2KO mice compared with WT and TLR2KO mice, respectively (#: AD vs. WT, p<0.05; +: AD-TLR2KO vs. WT, p<0.05). However, there was no significant difference in Aβ levels between AD and AD-TLR2KO mice (n=6 / group).