Research Paper Volume 11, Issue 17 pp 7257—7273

Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer’s disease

Figure 5. Thickness of cortex evaluated by T2-weighted images detected by 7 Tesla MRI system. The cortical thickness was measured by Image J software on T2-weighted images obtained from Paravision software. (A) Representative T2-weighted images used for measurement of cortical thickness (red line segment indicates the measured regions). (B) Results showed that cortical thickness was reduced in TLR2KO mice and AD-TLR2KO mice compared with WT mice (&: TLR2KO vs. WT, p<0.05; +: AD-TLR2KO vs. WT, p<0.05). (n= 4~6 / group).