Research Paper Volume 11, Issue 17 pp 7257—7273

Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer’s disease

Figure 6. Levels of GFAP in mouse brains. (A) Representative immunofluorescence staining of GFAP, a marker of astrocytes. (B) Representative bands of GFAP in brain tissues detected by Western blots. (C) GFAP significantly increased in AD mice and AD-TLR2KO mice compared with WT and TLR2 mice, respectively (#: AD vs. WT, p<0.05; +: AD-TLR2KO vs. WT, p<0.05). Moreover, the level of GFAP in AD-TLR2KO mice was significantly higher than that in AD mice (*: AD-TLR2KO vs. AD, p<0.05). (n= 6 / group).