Research Paper Volume 11, Issue 18 pp 7553—7569

Long non-coding RNA TUG1 enhances chemosensitivity in non-small cell lung cancer by impairing microRNA-221-dependent PTEN inhibition

Figure 6. miR-221 targets PTEN and PTEN is positively regulated by TUG1. (A) PTEN expression level in the sensitive and resistant groups of NSCLC; (B) dual luciferase report assay to verify the targeting relationship between miR-221 and PTEN; (C) regulation of miR-221 and TUG1 to PTEN expression level. * p < 0.05 versus the NC group; ** p < 0.01.