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Research Paper Volume 11, Issue 18 pp 7570—7586

Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation

Figure 2. LVIDd, LVIDs, LVEDP, LVMI and RVMI levels were decreased and LVEF, LVFS, +dp/dt max and -dp/dt max were increased by up-regulation of miR-93 or downregulation of LIMK1. (A) Comparison of echocardiograms of rats in each group; (B) Comparison of LVIDd, LVIDs, LVEF, LVFS, LVEDP, +dp/dt max, -dp/dt max, LVMI and RVMI in each group; * P < 0.05 vs. the sham group; # P < 0.05 vs. the mimics-NC group; &P < 0.05 vs. the siRNA-NC group; $P < 0.05 vs. the miR-93 mimics + OE-NC group; N = 8, the data were expressed as mean ± standard deviation; data analysis was performed by one-way ANOVA, and LSD-t method was used for pairwise comparison after ANOVA.